CX3CR1 (E9J4I) Rabbit mAb #19771
- F
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Rabbit IgG |
Application Key:
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Flow Cytometry (Live) | 1:50 - 1:200 |
Storage
Protocol
Specificity / Sensitivity
CX3CR1 (E9J4I) Rabbit mAb recognizes endogenous levels of total CX3CR1 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CX3CR1 protein.
Background
CX3C chemokine receptor 1 (CX3CR1) is a member of the seven-transmembrane G-protein coupled receptor (GPCR) family. It is a receptor for its sole ligand, CX3CL1, also known as fractalkine or neurotactin (1). Immune cells that express CX3CR1 include monocytes, macrophages, microglia, T helper (Th) 1 cells, CD8+ T effector/memory cells, NK cells, γδ T cells, and dendritic cells (DCs) (1,2). CX3CR1 has been implicated in inflammatory diseases, such as nephropathy and macular degeneration, and HIV co-receptors. It is emerging as an important player in the regulation of insulin secretion and beta cell function (3). In the brain, CX3CR1 expression is microglia-specific and regulates microglial recruitment to sites of neuroinflammation (1,2). Disruption of CX3CL1-CX3CR1 signaling promotes neurodegeneration in mouse models of Parkinson’s disease and amyotrophic lateral sclerosis but might be protective in Alzheimer’s disease (AD) (2,4,5).
Limited Uses
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