CYP11A1 Antibody #12491
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Product Name
- WB
- IP
Inquiry Info. # 12491
Please see our recommended alternatives.
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 50 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
CYP11A1, located in the inner membrane of mitochondria, cooperates with two coenzymes, ferredoxin and ferredoxin reductase, to carry out three successive oxidation-reduction reactions of cholesterol (3-5). In the adrenal cortex, testis, and ovary, CYP11A1 expression is regulated by the cAMP-PKA pathway (6), and the transcription factor SF1/NR5A1 has been shown to play a central role in mediating the cAMP signal on the CYP11A1 promoter within steroidogeneic cells of the adrenal cortex and gonads (7). Defects in CYP11A1 are the cause of adrenal insufficiency congenital with 46, XY sex reversal (AICSR), which is a rare disorder that can present as acute adrenal insufficiency in infancy or childhood (8,9).
- Nelson, D.R. et al. (1993) DNA Cell Biol 12, 1-51.
- Richards, J.S. et al. (1987) Recent Prog Horm Res 43, 231-76.
- Hanukoglu, I. and Jefcoate, C.R. (1980) J Biol Chem 255, 3057-61.
- Hanukoglu, I. et al. (1981) J Biol Chem 256, 4329-35.
- Hanukoglu, I. et al. (1981) J Biol Chem 256, 4321-8.
- Hu, M.C. et al. (1991) Biochem J 274 ( Pt 3), 813-7.
- Watanabe, N. et al. (1994) Eur J Biochem 222, 825-34.
- Tajima, T. et al. (2001) J Clin Endocrinol Metab 86, 3820-5.
- Katsumata, N. et al. (2002) J Clin Endocrinol Metab 87, 3808-13.
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