DcR2 (D13H4) Rabbit mAb #8049
- WB
- IP
Supporting Data
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 45-60 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Death receptor signaling can be controlled by a family of decoy receptors (DcR1, DcR2, and DcR3) that lack a cytoplasmic DD and inhibit death receptor-mediated apoptosis by competing for ligand binding (3-5). Expression of decoy receptors can contribute to chemosensitivity and may provide a mechanism for regulation of apoptosis in certain types of cancer (6-8).
- Nagata, S. (1997) Cell 88, 355-65.
- Thorburn, A. (2004) Cell Signal 16, 139-44.
- Sheridan, J.P. et al. (1997) Science 277, 818-21.
- Marsters, S.A. et al. (1997) Curr Biol 7, 1003-6.
- Pitti, R.M. et al. (1998) Nature 396, 699-703.
- Liu, X. et al. (2005) Cancer Res 65, 9169-75.
- Spalding, A.C. et al. (2002) Oncogene 21, 260-71.
- Bernard, D. et al. (2001) J Biol Chem 276, 27322-8.
Limited Uses
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