Render Target: STATIC
Render Timestamp: 2024-11-12T11:04:00.035Z
Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-05-10 22:32:15.925
Product last modified at: 2024-11-08T14:00:10.964Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Decorin (E2N2C) XP® Rabbit mAb #85786

Filter:
  • WB
  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 40, 100
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:100 - 1:400

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    For a carrier free (BSA and azide free) version of this product see product #55868.

    Protocol

    Specificity / Sensitivity

    Decorin (E2N2C) XP® Rabbit mAb recognizes endogenous levels of total decorin protein. This protein is heavily glycosylated, therefore, multiple bands or a smear may result from western blot analysis using this antibody.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro216 of human decorin protein.

    Background

    Decorin, named for its role in “decorating” type I collagen fibrils, is a collagen-binding proteoglycan that belongs to the small leucine-rich proteoglycan (SLRP) family (1). Through its binding to type I collagens and other important matrix proteins (e.g., fibronectin, thrombospondin, TGF-β), decorin plays a critically important role in assembly, maintenance, and physiological functions of the extracellular matrix. Notably, multiple research studies have reported anti-tumor functions for decorin and the related protein biglycan (2-4), implicating SLRP proteins as functionally important components of the tumor microenvironment (5). The anti-tumor effects of decorin have been ascribed to its interactions with cell surface receptors and associated signaling pathways (6), including those mediating inflammation, autophagy, and cell proliferation (7-9).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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