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XML generation date: 2024-10-31 20:01:07.887
Product last modified at: 2024-05-29T07:01:00.468Z
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PDP - Template Name: Antibody Sampler Kit
PDP - Template ID: *******4a3ef3a
  1. Products /
  2. Primary Antibodies /
  3. Demyelinating Disease Targets Antibody Sampler Kit

Demyelinating Disease Targets Antibody Sampler Kit #42135

    Product Information

    Kit Usage Information

    Protocols

    Product Description

    The Demyelinating Disease Targets Antibody Sampler Kit provides an economical means of detecting the protein components of myelin sheath. The kit includes enough antibodies to perform two western blot experiments with each primary antibody.

    Specificity / Sensitivity

    Each antibody in the Demyelinating Disease Targets Antibody Sampler Kit detects endogenous levels of its target protein. β3-Tubulin (D71G9) XP® Rabbit mAb detects endogenous levels of total β3-tubulin protein. β3-Tubulin (D71G9) XP® Rabbit mAb does not cross-react with tubulin isoforms expressed in non-neuronal cells. β3-Tubulin (D71G9) XP® Rabbit mAb is similar to TUJ1.

    Source / Purification

    Monoclonal antibodies are produced by immunizing rabbits with synthetic peptides corresponding to Arg188 of human MBP protein, Arg605 of human MAG protein, Pro1375 of human Caspr protein, Gln1040 of human Caspr2 protein, Arg881 of human neurofascin 155 protein, Thr1108 of human neurofascin 186 protein, residues near the carboxy terminus of human PLP1 protein, and the carboxy terminus of human β3-tubulin protein. MOG (E5K6T) XP® Rabbit mAb is produced by immunizing animals with recombinant protein specific to the extracellular membrane proximal amino terminus of human MOG protein.

    Background

    Myelin is the insulating material surrounding neuronal axons. The function of myelin is to promote action potential propagation down the axon to the axon terminal. Myelin is formed in the central nervous system (CNS) by specialized glial cells called oligodendrocytes and by Schwann cells in the peripheral nervous system (PNS). Oligodendrocytes and Schwann cells make concentric rings, called the myelin sheath, around the axon at regular intervals. These intervals, called nodes of ranvier, are enriched in structural proteins and ion channels, which help promote action potential propagation. Several proteins are enriched in the myelin sheath and likely help mediate the tight multi-layered membranes that make up the sheath. These proteins include myelin basic protein (MBP, [1]), myelin-associated glycoprotein (MAG, [2]), myelin proteolipid protein (PLP1, [3]) and  myelin-oligodendrocyte glycoprotein (MOG, [4]). Contactin-associated protein (Caspr) 1 & 2 (5,6) and neurofascin 155 & 186 (7,8) are nodes of ranvier-associated proteins that may play roles in generating the regular intervals of myelin along the axon. Expression of several of these proteins are altered in demyelinating diseases such as multiple sclerosis (MS). Additionally, mislocalization and/or altered expression of these proteins, compared to the axonal protein β3-tubulin, may represent altered myelin function. 

    Database Links

    UniProt ID: Q13509 , P02686 , Q9UHC6 , P78357 , O94856 , Q16653 , P60201 , P20916


    Entrez-Gene Id: 10381 , 4155 , 26047 , 8506 , 23114 , 4340 , 5354 , 4099


    Limited Uses

    Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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    XP is a registered trademark of Cell Signaling Technology, Inc.
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