Desmoglein 2 (8E5) Mouse mAb #88970
- WB
- IF
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 160 |
| Source/Isotype | Mouse IgG1 |
Application Key:
- WB-Western Blotting
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunofluorescence (Immunocytochemistry) | 1:200 - 1:800 |
Storage
Protocol
Specificity / Sensitivity
Desmoglein 2 (8E5) Mouse mAb recognizes endogenous levels of total desmoglein 2 protein. This antibody does not cross-react with desmoglein 1 or desmoglein 3 proteins.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the sequence of human desmoglein 2 protein.
Background
Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, which are intercellular junctions that mediate strong cell-cell adhesion and are linked to the intermediate filament cytoskeleton. Dysregulation of desmosomal protein expression affects both cell adhesion and communication, and has been shown to result in various human pathologies (1). Desmoglein 2 (DSG2) overexpression promotes lung cancer cell growth (2), and its expression is correlated with metastasis in squamous cell carcinoma of the skin (3).
Limited Uses
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