DKK1 (D5V6L) Rabbit mAb #48367
- WB
- IP
- IF
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 28-40 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
| Immunofluorescence (Immunocytochemistry) | 1:800 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
DKK1 was initially identified as an inducer of head formation in Xenopus embryos (7) and plays an important role in the regulation of bone mass (8-10). Research studies indicate that increased levels of DKK1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers (11,12), while DKK1 expression is decreased in malignant melanoma and colorectal cancers (13,14).
- Mao, B. et al. (2001) Nature 411, 321-5.
- Niehrs, C. (2006) Oncogene 25, 7469-81.
- Krupnik, V.E. et al. (1999) Gene 238, 301-13.
- Monaghan, A.P. et al. (1999) Mech Dev 87, 45-56.
- Mao, B. et al. (2002) Nature 417, 664-7.
- Davidson, G. et al. (2002) Development 129, 5587-96.
- Glinka, A. et al. (1998) Nature 391, 357-62.
- Baron, R. and Rawadi, G. (2007) Curr Osteoporos Rep 5, 73-80.
- MacDonald, B.T. et al. (2007) Bone 41, 331-9.
- Diarra, D. et al. (2007) Nat Med 13, 156-63.
- Forget, M.A. et al. (2007) Br J Cancer 96, 646-53.
- Yamabuki, T. et al. (2007) Cancer Res 67, 2517-25.
- Kuphal, S. et al. (2006) Oncogene 25, 5027-36.
- Aguilera, O. et al. (2006) Oncogene 25, 4116-21.
Limited Uses
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