DLL4 Antibody #2589
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 75-80 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
DLL4 expression is highly restricted to the vascular endothelium (7), and haploinsufficiency of DLL4 results in major defects in vascular systems in mouse (8-11). Blockade of DLL4 inhibits tumor growth in model systems (12-14).
- Wilson, A. and Radtke, F. (2006) FEBS Lett. 580, 2860-2868.
- Hansson, E.M. et al. (2004) Semin. Cancer Biol. 14, 320-328.
- Chiba, S. (2006) Stem Cells 24, 2437-2447.
- Bland, C.E. et al. (2003) J. Biol. Chem. 278, 13607-13610.
- Six, E. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 7638-7643.
- LaVoie, M.J. and Selkoe, D.J. (2003) J. Biol. Chem. 278, 34427-34437.
- Shutter, J.R. et al. (2000) Genes Dev. 14, 1313-1318.
- Gale, N.W. et al. (2004) Proc. Natl. Acad. Sci. USA 101, 15949-15954.
- Krebs, L.T. et al. (2004) Genes Dev. 18, 2469-2473.
- Duarte, A. et al. (2004) Genes Dev. 18, 2474-2478.
- Hellström, M. et al. (2007) Nature 445, 776-780.
- Noguera-Troise, I. et al. (2006) Nature 444, 1032-1037.
- Lobov, I.B. et al. (2007) Proc. Natl. Acad. Sci. USA 104, 3219-3224.
- Scehnet, J.S. et al. (2007) Blood 109, 4753-4760.
Limited Uses
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