DLL4 (D7N3H) Rabbit mAb #96406
- WB
- IP
- IF
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 75-80 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:200 |
| Immunofluorescence (Immunocytochemistry) | 1:400 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
DLL4 expression is highly restricted to the vascular endothelium (7), and haploinsufficiency of DLL4 results in major defects in vascular systems in mouse (8-11). Blockade of DLL4 inhibits tumor growth in model systems (12-14).
- Wilson, A. and Radtke, F. (2006) FEBS Lett. 580, 2860-2868.
- Hansson, E.M. et al. (2004) Semin. Cancer Biol. 14, 320-328.
- Chiba, S. (2006) Stem Cells 24, 2437-2447.
- Bland, C.E. et al. (2003) J. Biol. Chem. 278, 13607-13610.
- Six, E. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 7638-7643.
- LaVoie, M.J. and Selkoe, D.J. (2003) J. Biol. Chem. 278, 34427-34437.
- Shutter, J.R. et al. (2000) Genes Dev 14, 1313-8.
- Gale, N.W. et al. (2004) Proc Natl Acad Sci U S A 101, 15949-54.
- Krebs, L.T. et al. (2004) Genes Dev 18, 2469-73.
- Duarte, A. et al. (2004) Genes Dev 18, 2474-8.
- Hellström, M. et al. (2007) Nature 445, 776-80.
- Noguera-Troise, I. et al. (2006) Nature 444, 1032-7.
- Lobov, I.B. et al. (2007) Proc Natl Acad Sci U S A 104, 3219-24.
- Scehnet, J.S. et al. (2007) Blood 109, 4753-60.
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