DR3 Antibody #3254
Inquiry Info. # 3254
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Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 48 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
DR3/WSL-1/Apo-3/TRAMP/LARD is a TNFR family member containing the characteristic extracellular cysteine-repeats, transmembrane region, and intracellular DD (3-7). DR3 is activated by its ligand Apo-3L/TWEAK to induce apoptosis and activation of NF-κB (8,9). Like TNF-R1, DR3 binds to the DD adaptor protein TRADD, which can then associate with other DD proteins like FADD and RIP as well as members of the TRAF family (3,4). Tissue expression of DR3 is very restricted, primarily seen on the surface of activated thymocytes and lymphocytes and plays an important role in thymocyte negative selection (3,4,10). Studies have also indicated an association with DR3 and rheumatoid arthritis (11,12).
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- Marsters, S.A. et al. (1996) Curr. Biol. 6, 1669-1676.
- Bodmer, J.L. et al. (1997) Immunity 6, 79-88.
- Screaton, G.R. et al. (1997) Proc. Natl. Acad. Sci. USA 94, 4615-4619.
- Marsters, S.A. et al. (1998) Curr. Biol. 8, 525-528.
- Kaptein, A. et al. (2000) FEBS Lett. 485, 135-141.
- Wang, E.C. et al. (2001) Mol. Cell Biol. 21, 3451-3461.
- Osawa, K. et al. (2004) Genes Immun. 5, 439-443.
- Borysenko, C.W. et al. (2005) Biochem. Biophys. Res. Commun. 328, 794-799.
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