DR3 (D5Q2R) Rabbit mAb #45901
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 55-60 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
DR3/WSL-1/Apo-3/TRAMP/LARD is a TNFR family member containing the characteristic extracellular cysteine-repeats, transmembrane region, and an intracellular DD (3-7). DR3 is activated by its ligand Apo-3L/TWEAK to induce apoptosis and activation of NF-κB (8,9). Like TNF-R1, DR3 binds to the DD adaptor protein TRADD, which can then associate with other DD proteins like FADD and RIP as well as members of the TRAF family (3,4). Tissue expression of DR3 is very restricted, primarily seen on the surface of activated thymocytes and lymphocytes and plays an important role in thymocyte negative selection (3,4,10). Studies have also indicated an association with DR3 and rheumatoid arthritis (11,12).
- Nagata, S. (1997) Cell 88, 355-65.
- Thorburn, A. (2004) Cell Signal 16, 139-44.
- Chinnaiyan, A.M. et al. (1996) Science 274, 990-2.
- Kitson, J. et al. (1996) Nature 384, 372-5.
- Marsters, S.A. et al. (1996) Curr Biol 6, 1669-76.
- Bodmer, J.L. et al. (1997) Immunity 6, 79-88.
- Screaton, G.R. et al. (1997) Proc Natl Acad Sci U S A 94, 4615-9.
- Marsters, S.A. et al. (1998) Curr Biol 8, 525-8.
- Kaptein, A. et al. (2000) FEBS Lett 485, 135-41.
- Wang, E.C. et al. (2001) Mol Cell Biol 21, 3451-61.
- Osawa, K. et al. (2004) Genes Immun 5, 439-43.
- Borysenko, C.W. et al. (2005) Biochem Biophys Res Commun 328, 794-9.
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