DR6 (E8D2I) Rabbit mAb #93026
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 80, 120 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:200 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
DR6, also known as TNFRSF21, is a TNFR family member able to induce apoptosis as well as activation of NF-κB and JNK (3). Expression of DR6 is upregulated by NF-κB signaling (4). DR6 appears to play a critical role in the activation and differentiation of T and B lymphocytes (5,6). In the nervous system, β-amyloid precursor protein (APP) activates DR6 to trigger neuronal degeneration (7).
- Nagata, S. (1997) Cell 88, 355-65.
- Thorburn, A. (2004) Cell Signal 16, 139-44.
- Pan, G. et al. (1998) FEBS Lett 431, 351-6.
- Kasof, G.M. et al. (2001) Oncogene 20, 7965-75.
- Zhao, H. et al. (2001) J Exp Med 194, 1441-8.
- Schmidt, C.S. et al. (2003) J Exp Med 197, 51-62.
- Nikolaev, A. et al. (2009) Nature 457, 981-9.
Limited Uses
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