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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77

DRAK2 (33D7) Rabbit mAb #2294

Filter:
  • WB
  • IP
  • IHC
Western Blotting Image 1: DRAK2 (33D7) Rabbit mAb
Western blot analysis of total cell lysates from BaF3 and mouse thymocytes, using DRAK2 (33D7) Rabbit mAb.

To Purchase # 2294

Cat. # Size Qty. Price
2294T 20 µl
$152
2294S 100 µl
$336

Supporting Data

REACTIVITY M
SENSITIVITY Endogenous
MW (kDa) 43
Source/Isotype Rabbit IgG
Application Key:
  • WB-Western Blotting 
  • IP-Immunoprecipitation 
  • IHC-Immunohistochemistry 
Species Cross-Reactivity Key:
  • M-Mouse 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000
Immunoprecipitation 1:50
Immunohistochemistry (Paraffin) 1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

DRAK2 (33D7) Rabbit mAb detects endogenous levels of total DRAK2 protein.

Species Reactivity:

Mouse

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp315 of mouse DRAK2.

Background

DRAK2 (DAP kinase related apoptosis inducing protein kinase 2) is a member of the novel DAP (death associated protein) pro-apoptotic kinase family (1). Overexpression of DRAK2 in NIH/3T3 cells induces morphological changes associated with apoptosis, which are likely to occur in a p53-dependent manner (1,2). DRAK2 is preferentially expressed in lymphoid tissues and regulates the TCR activation threshold during thymocyte selection (3). Indeed, T cells from DRAK2(-/-) mice exhibit enhanced sensitivity to T cell receptor-mediated stimulation and have a reduced requirement for co-stimulation (4).
For Research Use Only. Not For Use In Diagnostic Procedures.
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