DYNLL1/LC8 (E6W7R) Rabbit mAb #82007
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 10 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Loss of DYNLL1 in BRCA1-mutant cancer cells restores homologous recombination by allowing DNA end resection, conferring resistance to platinum and PARP inhibitor therapies (3). DYNLL1 regulation of DNA repair pathways likely occurs through its interaction with end resection machinery and 53BP1 (3,4). Upregulation of DYNLL1 has been associated with chemoresistance and progression of human cancer (5-7).
- Jespersen, N. and Barbar, E. (2020) Trends Biochem Sci 45, 375-384.
- Rapali, P. et al. (2011) FEBS J 278, 2980-96.
- He, Y.J. et al. (2018) Nature 563, 522-526.
- Becker, J.R. et al. (2018) Nat Commun 9, 5406.
- Berkel, C. and Cacan, E. (2021) Biochem Biophys Res Commun 570, 74-81.
- Berkel, C. and Cacan, E. (2020) Exp Mol Pathol 117, 104567.
- Wong, D.M. et al. (2016) Cell Rep 14, 1488-1499.
Limited Uses
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