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Primary Antibodies /
EGR1 Antibody

EGR1 Antibody #4152

We recommend the following alternatives

Product Name

4153 EGR1 (15F7) Rabbit mAb

4154 EGR1 (44D5) Rabbit mAb

Inquiry Info. # 4152

Please see our recommended alternatives.

Supporting Data

REACTIVITY
SENSITIVITY	Endogenous
MW (kDa)	80
SOURCE	Rabbit

Product Information

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Specificity / Sensitivity

EGR1 antibody detects endogenous levels of total EGR1.

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal sequence of human EGR1. Antibodies are purified by protein A and peptide affinity chromatography.

Background

EGR family members are transcriptional factors that contain three repetitive zinc finger DNA binding domains which bind to EGR response elements (ER) to regulate target gene expression (1). The expression of EGR family members is induced by growth factors, with EGR1 expression being induced by NGF (1,2). Increased EGR1 expression activates transcription of other signaling molecules, including CDK5 and tyrosine hydroxylase, and exerts long term effects on neural cell growth and differentiation (2,3).

Database Links

UniProt ID: P18146

Entrez-Gene Id: 1958

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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