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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

Emerin (L12) Antibody #2659

Filter:
  • WB
  • IP
Western Blotting Image 1: Emerin (L12) Antibody
Western blot analysis of extracts from various cell types using Emerin (L12) Antibody.

To Purchase # 2659

Cat. # Size Qty. Price Ships
2659S 100 µl
$306 Jan 23

Supporting Data

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa) 30
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
  • IP-Immunoprecipitation 
Species Cross-Reactivity Key:
  • H-Human 

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000
Immunoprecipitation 1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

Emerin (L12) Antibody detects endogenous levels of total Emerin protein.

Species Reactivity:

Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu12 of human Emerin. Antibodies are purified by peptide affinity chromatography.

Background

Emerin is a broadly expressed integral protein of the nuclear inner membrane (1). It contains a LEM domain and binds to several nuclear proteins, such as BAF (barrier-to-autointegration factor) and A- and B-type lamins, which are important in nuclear functions (2-5). Emerin may regulate gene expression through binding to other transcriptional regulators (6,7). Emerin binds to β-catenin and inhibits its nuclear accumulation (8). Recent studies demonstrate that emerin is required for HIV-1 infectivity (9). Mutations in the gene encoding emerin (EMD) are a major cause of Emery-Dreifuss muscular dystrophy (EDMD), a disorder characterized by progressive skeletal muscle weakening (10).
For Research Use Only. Not For Use In Diagnostic Procedures.
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