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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

Erlin-1 Antibody #2958

Filter:
  • WB
Western Blotting Image 1: Erlin-1 Antibody
Western blot analysis of extracts from human U937 and ovcar8 cell lines using Erlin-1 Antibody.

To Purchase # 2958

Cat. # Size Qty. Price Ships
2958S 100 µl
$306 Jan 22

Supporting Data

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa) 43
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

Erlin-1 Antibody detects endogenous levels of total human erlin-1 protein.

Species Reactivity:

Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly320 of human erlin-1. Antibodies are purified by peptide affinity chromatography.

Background

Erlin-1 and erlin-2 (SPFH1 and SPFH2) are SPFH domain-containing proteins that belong to the prohibitin family (1,2). The N-termal domain of erlin proteins contains ER-targeting sequences responsible for their translocation to the endoplasmic reticulum (ER) (3). In the ER, erlin-1 and erlin-2 specifically associate with the detergent resistant lipid raft microdomain of the membrane (3). Erlin-1 may be involved in dentritic cell activation (4) and erlin-2 has been shown to regulate the ER-associated degradation (ERAD) pathway by interacting with endogenous substrates and resulting in their polyubiquitination and degradation (5).
For Research Use Only. Not For Use In Diagnostic Procedures.
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