Render Target: STATIC
Render Timestamp: 2024-12-20T12:15:18.998Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 01:58:16.807
Product last modified at: 2024-12-17T18:49:38.511Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

ETV5 (E5G9V) Rabbit mAb #16274

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa) 68
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    ETV5 (E5G9V) Rabbit mAb recognizes endogenous levels of total ETV5 protein.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a recombinant protein fragment specific to human ETV5 protein.

    Background

    ETV5 (ERM) is a member of the PEA3 (polyomavirus enhancer activator 3) subfamily of the E26 transformation-specific (ETS) DNA-binding transcription factors (1,2). PEA3 subfamily members are considered as oncogenic transcriptional factors due to their close association with and contribution to cancer development. The subfamily of ETS proteins consists of three members: ETV1, ETV4, and ETV5. RAS/MAPK and PKA are identified to be the upstream activator of ETV5 by phosphorylation of the target at serine residues (3-5). In addition to cancer promoting effect, ETV5 also regulates many basic cellular functions during normal development, including embryonic stem cell differentiation (6,7), neuronal cell growth, differentiation, and neuron-dendrite network establishment (8,9), reproduction organ development (10,11), as well as cellular fatty acid metabolism and obesity (12,13).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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