Render Target: STATIC
Render Timestamp: 2024-12-20T10:43:52.657Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-11-18 16:03:15.508
Product last modified at: 2024-11-19T09:00:16.328Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

EXOSC10 (F4Q2B) Rabbit mAb #34735

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 100
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    EXOSC10 (F4Q2B) Rabbit mAb recognizes endogenous levels of total EXOSC10 protein. This antibody detects a 32 kDa band of unknown origin.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly877 of human EXOSC10 protein.

    Background

    Exosome component 10 (EXOSC10), also known as RRP6 or autoantigen PM/Scl-100, is a 3’-5’ nuclear component of the exosome complex with 3’-5’ exonuclease activity. EXOSC10 is essential for the 3’ end formation of 5.8S rRNA, as well as the degradation of improperly spliced or polyadenylated mRNAs (1-3). Additionally, EXOSC10 regulates the proper 3’ formation of small nucleolar RNAs (snoRNAs) (4). EXOSC10 is the antibody target in polymyositis-scleroderma overlap, an autoimmune disease (5-7).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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