Render Target: STATIC
Render Timestamp: 2025-01-21T16:24:11.209Z
Commit: da7e4f2f0d1aed1f1f8e20e4e2ecab8f33cbd595
XML generation date: 2024-09-20 06:19:19.410
Product last modified at: 2025-01-01T09:02:15.841Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

FAAH1 Antibody #9179

Filter:
  • WB
  • IP
Western Blotting Image 1: FAAH1 Antibody
Western blot analysis of extracts from INS-1 cells and rat brain using FAAH1 Antibody.

To Purchase # 9179

Cat. #

Size

9179S
100 µl

Supporting Data

REACTIVITY R
SENSITIVITY Endogenous
MW (kDa) 60
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
  • IP-Immunoprecipitation 
Species Cross-Reactivity Key:
  • R-Rat 

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000
Immunoprecipitation 1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

FAAH1 Antibody detects endogenous levels of total FAAH1 protein.

Species Reactivity:

Rat

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of rat FAAH1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Endogenous cannabinoids have been implicated in addictive behaviors and drug abuse (1). Fatty-acid amide hydrolase 1 (FAAH1) is a plasma membrane-bound hydrolase that converts oleamide to oleic acid (2). This hydrolase also converts the cannabinoid anandamide, the endogenous ligand for the CB1 cannabinoid receptor, to arachidonic acid, suggesting a role in fatty-acid amide inactivation (2). Mice lacking FAAH1 have significantly higher levels of anandamide in the brain and show decreased sensitivity to pain, further indicating a role for FAAH1 in the regulation of endocannabinoid signaling in vivo (3). FAAH1 null mice also demonstrate an increased preference for alcohol and an increased voluntary uptake of alcohol as compared to wild-type mice, indicating a role of FAAH1 in modulating addictive behaviors (1).
For Research Use Only. Not For Use In Diagnostic Procedures.
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