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Product last modified at: 2025-04-02T12:15:21.023Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

FABP4 Antibody #2120

Filter:
  • WB
Western Blotting Image 1: FABP4 Antibody
Western blot analysis of extracts from NIH/3T3 and 3T3-L1 cells using FABP4 Antibody.

To Purchase # 2120

Cat. # Size Qty. Price
2120S 100 µl
$306

Supporting Data

REACTIVITY H M
SENSITIVITY Endogenous
MW (kDa) 15
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 
  • M-Mouse 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

FABP4 Antibody detects endogenous levels of total FABP4 protein. This antibody may cross react with other FABP family members.

Species Reactivity:

Human, Mouse

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of mouse FABP4. Antibodies are purified by peptide affinity chromatography.

Background

Fatty acid binding proteins (FABPs) bind to fatty acids and other lipids to function as cytoplasmic lipid chaperones (1). They participate in the transport of fatty acids and other lipids to various cellular pathways (2). The predominant fatty acid binding protein found in adipocytes is FABP4, also called adipocyte fatty acid binding protein or aP2. FABP4 is also expressed in macrophages (3). FABP4 knockout mice fed a high-fat and high-calorie diet become obese but develop neither insulin resistance nor diabetes, suggesting that this protein might be a link between obesity and insulin resistance and diabetes (4). Mice deficient in both FABP4 and ApoE show protection against atherosclerosis when compared with mice deficient only in ApoE (3). Mice carrying a FABP4 genetic variant exhibit both reduced FABP4 expression and a reduced potential for developing type 2 diabetes and coronary heart disease. A related study in humans indicated a similar pattern, suggesting that FABP4 may be a potential therapeutic target in the treatment of these disorders (1).
For Research Use Only. Not For Use In Diagnostic Procedures.
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