Render Target: STATIC
Render Timestamp: 2024-12-20T11:04:14.126Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-11-13 21:46:07.609
Product last modified at: 2024-12-17T18:58:20.731Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

FAM134B Antibody #61011

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 70
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    FAM134B Antibody recognizes endogenous levels of total FAM134B protein.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human FAM134B protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Family with sequence similarity 134, member B (FAM134B), also referred to as JK-1 and RETREG1, is a cis-Golgi endoplasmic reticulum (ER) transmembrane protein that plays a role in ER homeostasis and may contribute to several human diseases (1). FAM134B contains a conserved LC3-interacting domain (LIR) that facilitates binding to LC3 and GABARAP family members and targets impaired ER to the autophagosome for degradation by ER-phagy (2). Deletion of FAM134B leads to ER expansion and stress-induced apoptosis (2). Expression of FAM134B has been linked to a number of pathological conditions, including viral infection, cancer, and neuronal disorders (1). FAM134B can potentially inhibit viral infection, as demonstrated by studies of FAM134B knockouts that resulted in significantly higher rates of Ebola virus replication (3). Mutations in FAM134B that lead to an accumulation of misfolded proteins have also been associated with neuronal sensory disorders (2,4,5). The expression and mutational state of FAM134B can also have varying effects on cancer. The oncogenic effects of FAM134B were described in esophageal squamous carcinoma, whereas it appears to have tumor suppressor activity in colorectal cancer (6-8).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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