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Commit: 461ca8d8fe5b1efd4c01fc87e5b5eb592e2d154a
XML generation date: 2025-03-07 13:17:08.286
Product last modified at: 2025-03-28T20:30:10.346Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

FATP2/SLC27A2 (E8F8O) Rabbit mAb #78771

Filter:
  • WB
  • IP
Western Blotting Image 1: FATP2/SLC27A2 (E8F8O) Rabbit mAb
Western blot analysis of extracts from various cell lines using FATP2/SLC27A2 (E8F8O) Rabbit mAb (upper) or GAPDH (D16H11) XP® Rabbit mAb #5174 (lower). Low expression of FATP2/SLC27A2 protein in MDA-MB-231 cells is consistent with the predicted expression pattern.

To Purchase # 78771

Cat. # Size Qty. Price
78771T 20 µl
$153
78771S 100 µl
$339

Supporting Data

REACTIVITY H M
SENSITIVITY Endogenous
MW (kDa) 70
Source/Isotype Rabbit IgG
Application Key:
  • WB-Western Blotting 
  • IP-Immunoprecipitation 
Species Cross-Reactivity Key:
  • H-Human 
  • M-Mouse 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000
Immunoprecipitation 1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

FATP2/SLC27A2 (E8F8O) Rabbit mAb recognizes endogenous levels of total FATP2/SLC27A2 protein. This antibody does not cross-react with FATP1/SLC27A1 protein.

Species Reactivity:

Human, Mouse

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val381 of human FATP2/SLC27A2 protein.

Background

Fatty acid transport protein 2 (FATP2), also known as solute carrier family 27 member 2 (SLC27A2), transports long-chain fatty acids into cells at the cell membrane. FATP2/SLC27A2 also functions as a very long-chain acyl-CoA synthetase in the endoplasmic reticulum to activate very long-chain fatty acids (1). Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are pathologically activated neutrophils that accumulate in many diseases. The immunosuppressive activity of PMN-MDSCs is critical in regulating immune responses in cancer. Studies show that FATP2/SLC27A2 expression is upregulated in PMN-MDSCs. FATP2/SLC27A2 mediates the suppressive activity of PMN-MDSCs by increasing the uptake of arachidonic acid and synthesis of prostaglandin E2. In addition, deletion of FATP2/SLC27A2 is shown to abolish the suppressive activity of PMN-MDSCs (2). These results suggest that targeting FATP2/SLC27A2 may increase anti-tumor immunity (2,3).
For Research Use Only. Not For Use In Diagnostic Procedures.
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