Render Target: STATIC
Render Timestamp: 2024-11-22T11:44:50.856Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 01:59:07.630
Product last modified at: 2024-11-15T19:45:07.888Z
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

FcεRIA (E6D9L) Rabbit mAb #16992

Filter:
  • WB

    Supporting Data

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa) 45-65
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    FcεRIA (E6D9L) Rabbit mAb recognizes endogenous levels of total FcεRIA protein.

    Species Reactivity:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with mouse FcεRIA recombinant protein.

    Background

    FcεRI, the high affinity IgE receptor complex, is made up of an α-chain, a β-chain, and a homodimer of two disulphide-linked γ-chains (1-4). It is expressed by mast cells, basophils, and antigen-presenting cells (1-4). The α-chain, FcεRIA, binds the Fc portion of IgE, which initiates antigenic crosslinking and leads to an allergic response, resulting in secretion of molecules such as interleukin-4 (IL-4), interleukin-6 (IL-6), tumor-necrosis factor-α (TNF-α), and granulocyte-macrophage colony-stimulating factor (GM-CSF) (1-5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.