FcRL3 (E1V4L) Rabbit mAb #26402
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 100, 120 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
FcRL3 (E1V4L) Rabbit mAb recognizes endogenous levels of total FcRL3 protein. This antibody detects a 42 kDa band of unknown origin in some cell lines.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp70 of human FcRL3 protein.
Background
FcRL3 (Fc receptor-like protein 3, IRTA3, FcRH3) is a member of the Fc receptor-like family of proteins, which show high structural homology to classical Fc receptors in their extracellular domains (1,2). FcRL3 is a type I transmembrane protein, containing a long cytoplasmic tail with one ITAM, one ITIM, and an ITAM-like region (1,2). FcRL3 is primarily expressed in B lymphocytes in lymph nodes and germinal centers, although it has also been found in NK cells and subsets of T cells (1-6). Functional variants of the FcRL3 gene have been associated with autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), autoimmune thyroiditis, and autoimmune pancreatitis (3-6). FcRL3 has inhibitory potential on BCR-mediated signaling, possibly through the association of ITIMs with phosphatases SHIP, SHP-1, and SHP-2 (4).
Limited Uses
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