Render Target: STATIC
Render Timestamp: 2025-01-22T14:08:35.353Z
Commit: da7e4f2f0d1aed1f1f8e20e4e2ecab8f33cbd595
XML generation date: 2024-05-21 18:08:07.415
Product last modified at: 2025-01-01T09:02:38.524Z
Cell Signaling Technology Logo

Basket Updated

0

Items added

1% for the planet logo
PDP - Template Name: Antibody Duet
PDP - Template ID: *******ad0fa02

PhosphoPlus® FGF Receptor 1 (Tyr653/654) Antibody Duet #58851

PhosphoPlus® FGF Receptor 1 (Tyr653/654) Antibody Duet: Image 1
Western blot analysis of extracts from A-204 cells, untreated (-) or treated with heparin (1 μg/mL, 5 min) followed by the Human Basic Fibroblast Growth Factor (hFGF basic/FGF2) #61977 (100 ng/mL, 5 min, +), using Phospho-FGF Receptor 1 (Tyr653/654) (D4X3D) Rabbit mAb (upper) and FGF Receptor 1 (D8E4) XP® Rabbit mAb #9740 (lower).

To Purchase # 58851

Cat. # Size Qty. Price Ships
58851S 1 Kit
$651
  • Product Includes
  • Related Products
Product IncludesQuantityReactivityMW(kDa)Isotype
FGF Receptor 1 (D8E4) XP® Rabbit mAb #9740100 µlH M R Mk92 , 120, 145Rabbit IgG
Phospho-FGF Receptor 1 (Tyr653/654) (D4X3D) Rabbit mAb #52928100 µlH120, 145Rabbit IgG

Product Information

Product Description

PhosphoPlus® Duets from Cell Signaling Technology (CST) provide a means to assess protein activation status. Each Duet contains an activation-state and total protein antibody to your target of interest. These antibodies have been selected from CST's product offering based upon superior performance in specified applications.

Background

Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR1 (flg), FGFR2 (bek, KGFR), FGFR3, and FGFR4. Each receptor contains an extracellular ligand-binding domain, a transmembrane domain, and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components, such as Crk and PLCγ (4,5).

Pathways

Explore pathways related to this product.


For Research Use Only. Not For Use In Diagnostic Procedures.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
PhosphoPlus is a registered trademark of Cell Signaling Technology, Inc.
XP is a registered trademark of Cell Signaling Technology, Inc.
All other trademarks are the property of their respective owners. Visit our Trademark Information page.