FGF Receptor 2 Antibody #3116
- WB
Inquiry Info. # 3116
Please see our recommended alternatives.
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 145 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
FGFR-2 has several splicing isoforms, with ligand specificity largely determined by alternative splicing of exons 8 (IIIb) and 9 (IIIc). Alternative splicing is cell type specific, resulting in isoforms showing various tissue distribution and biological activities (6,7). Mutations in the corresponding FGFR-2 gene cause syndromes characterized by facial and limb defects, including LADD Syndrome, Crouzon Syndrome, Beare-Stevenson Cutis Grata Syndrome, Pfieffer Syndrome, Apert Syndrome and Jackson-Weiss Syndrome. Mutations and altered expression of FGFR-2 may also be seen in cases of gastric, endometrial and breast cancer (8).
- Powers, C.J. et al. (2000) Endocr Relat Cancer 7, 165-97.
- Reilly, J.F. et al. (2000) J Biol Chem 275, 7771-8.
- Mohammadi, M. et al. (1996) Mol Cell Biol 16, 977-89.
- Mohammadi, M. et al. (1991) Mol Cell Biol 11, 5068-78.
- Larsson, H. et al. (1999) J Biol Chem 274, 25726-34.
- Muh, S.J. et al. (2002) J Biol Chem 277, 50143-54.
- Coutts, J.C. and Gallagher, J.T. (1995) Immunol Cell Biol 73, 584-9.
- Eswarakumar, V.P. et al. (2005) Cytokine Growth Factor Rev 16, 139-49.
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