FKBP10 (E8M4E) Rabbit mAb #57551
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 78 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
FKBP10, also known as FKBP65 (65 kDa FK506-binding protein), has four tandem PPIase domains and is an endoplasmic reticulum (ER) resident protein, where it modulates the folding and trafficking of secretory proteins. FKBP10 plays an important role in collagen folding and secretion and its mutation is associated with osteogenesis imperfecta (4-6), and it is considered as a therapeutic target for idiopathic pulmonary fibrosis (IPF) (7,8). Recent reports suggest that FKBP10 may be a biomarker or therapeutic target for several different cancers (9-11).
- Bonner, J.M. and Boulianne, G.L. (2017) Cell Signal 38, 97-105.
- Tong, M. and Jiang, Y. (2015) Curr Mol Pharmacol 9, 48-65.
- Ghartey-Kwansah, G. et al. (2018) BMC Dev Biol 18, 7.
- Ishikawa, Y. et al. (2017) J Biol Chem 292, 17216-17224.
- Li, S. et al. (2020) Front Genet 11, 984.
- Lietman, C.D. et al. (2017) J Bone Miner Res 32, 1354-1367.
- Staab-Weijnitz, C.A. et al. (2015) Am J Respir Crit Care Med 192, 455-67.
- Knüppel, L. et al. (2018) Respir Res 19, 67.
- Ge, Y. et al. (2017) Urol Int 98, 169-176.
- Liang, L. et al. (2019) Oncol Rep 42, 615-628.
- Gong, L.B. et al. (2020) Onco Targets Ther 13, 7399-7409.
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