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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77

FoxA1/HNF3α (IHC578) Mouse mAb #59197

Filter:
  • IHC
Immunohistochemistry Image 1: FoxA1/HNF3α (IHC578) Mouse mAb

Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using FoxA1/HNF3α (IHC578) Mouse mAb.

To Purchase # 59197

Cat. # Size Qty. Price
59197S 100 µl
$350

Supporting Data

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa)
Source/Isotype Mouse IgG1
Application Key:
  • IHC-Immunohistochemistry 
Species Cross-Reactivity Key:
  • H-Human 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Immunohistochemistry (Paraffin) 1:800 - 1:3200

Storage

Supplied in a Tris-based buffer with 1% BSA and less than 0.1% sodium azide. Stable for 24 months when stored at 4°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

FoxA1/HNF3α (IHC578) Mouse mAb recognizes endogenous levels of total FoxA1/HNF3α protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a recombinant protein corresponding to human FoxA1/HNF3α protein.

Background

Forkhead box protein A1 (FoxA1, HNF3α) is a transcription factor required for the development of endoderm-derived organs, such as liver, lung, and prostate (1). FoxA1 functions as a pioneer factor that is recruited primarily to the distant enhancers to change chromatin structure for transcription in a cell type-specific manner (2,3). The FoxA1 transcription factor is implicated in various diseases, playing a role in hormone-dependent disorders, such as breast and prostate cancers (4). The treatment of relapsing-remitting multiple sclerosis patients with IFN-β results in FoxA1-induced stimulation of a novel population of FoxA1(+) regulatory T cells, suggesting a possible immunosuppressive role for FoxA1 (5).

Pathways

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For Research Use Only. Not For Use In Diagnostic Procedures.
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