FoxC1 (D8A6) Rabbit mAb #8758
- WB
- IP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 75 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:200 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
FoxC1 (FKHL7, FREAC3) is one of two mammalian FoxC subfamily members. Along with FoxC2, it is expressed in paraxial mesoderm where it functions to promote somitogenesis, myogenesis, and vascular development, possibly under Wnt/β-catenin regulation (5). Mutations in FoxC1 are implicated in anterior segment dysgenesis (ASD) disorders, including congenital glaucoma and Axenfeld-Rieger syndrome (6). Research studies have shown that alterations in FoxC1 expression are linked to breast cancer invasiveness (7,8) and have been shown to modulate proliferation and migration of breast cancer cells in vitro (9).
- Myatt, S.S. and Lam, E.W. (2007) Nat Rev Cancer 7, 847-59.
- Jackson, B.C. et al. (2010) Hum Genomics 4, 345-52.
- Hannenhalli, S. and Kaestner, K.H. (2009) Nat Rev Genet 10, 233-40.
- Benayoun, B.A. et al. (2011) Trends Genet 10, 224-32.
- Savage, J. et al. (2010) Differentiation 79, 31-40.
- Weisschuh, N. et al. (2008) Clin Genet 74, 476-80.
- Dejeux, E. et al. (2010) Mol Cancer 9, 68.
- Muggerud, A.A. et al. (2010) Breast Cancer Res 12, R3.
- Ray, P.S. et al. (2010) Cancer Res 70, 3870-6.
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