FoxK2 (E7C5H) Rabbit mAb #28712
- WB
- IP
- ChIP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 79 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- ChIP-Chromatin Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:10 - 1:50 |
| Immunoprecipitation | 1:200 |
| Chromatin IP | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
FoxK1 and FoxK2 belong to one of the subfamilies of Fox proteins and contain a forkhead-associated (FHA) domain and a conserved forkhead DNA-binding domain (5). FoxK2 was initially identified as a regulator of IL-2 transcription (6). Studies have shown that FoxK2 binds to DNA harboring G/T mismatches and might be involved in DNA mismatch repair (7). FoxK2 also mediates the oncogenic function of adenovirus (Adv) oncoprotein E1A and papillomavirus E6 proteins via association with these proteins (8). Moreover, FoxK2 promotes AP-1-mediated transcriptional regulation by enhancing the recruitment of AP-1 to chromatin (9). FoxK2 is phosphorylated at Ser368 and Ser423 in a CDK1-cyclin B-dependent manner and is involved in cell cycle regulation (10).
- Myatt, S.S. and Lam, E.W. (2007) Nat Rev Cancer 7, 847-59.
- Jackson, B.C. et al. (2010) Hum Genomics 4, 345-52.
- Hannenhalli, S. and Kaestner, K.H. (2009) Nat Rev Genet 10, 233-40.
- Benayoun, B.A. et al. (2011) Trends Genet 27, 224-32.
- Katoh, M. and Katoh, M. (2004) Int J Mol Med 14, 127-32.
- Li, C. et al. (1991) Proc Natl Acad Sci USA 88, 7739-43.
- Fujii, Y. and Nakamura, M. (2010) J Biochem 147, 705-9.
- Komorek, J. et al. (2010) J Virol 84, 2719-31.
- Ji, Z. et al. (2012) Mol Cell Biol 32, 385-98.
- Marais, A. et al. (2010) J Biol Chem 285, 35728-39.
Limited Uses
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