FoxP1 (D35D10) XP® Rabbit mAb (BSA and Azide Free) #85650
- WB
- IHC
- F
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 82-90 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.
Formulation
For standard formulation of this product see product #4402
Storage
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
FoxP1 plays an important role in cardiac valve and B cell development. Targeted deletion of FoxP1 in mice results in embryonic death at E14.5 with severe defects in cardiac outflow development, endocardial cushion morphogenesis, and myocyte proliferation and maturation (6). The FoxP1 gene is located on chromosome 3p14.1 and loss of heterozygosity of this region in multiple cancer types suggests a role for FoxP1 as a tumor suppressor (7). Alternatively, FoxP1 may also act as an oncogene as it is highly expressed in a variety of B cell malignancies and is frequently involved in chromosome translocation (8,9).
- Myatt, S.S. and Lam, E.W. (2007) Nat Rev Cancer 7, 847-59.
- Shu, W. et al. (2001) J Biol Chem 276, 27488-97.
- Lu, M.M. et al. (2002) Gene Expr Patterns 2, 223-8.
- Koon, H.B. et al. (2007) Expert Opin Ther Targets 11, 955-65.
- Li, S. et al. (2004) Mol Cell Biol 24, 809-22.
- Wang, B. et al. (2004) Development 131, 4477-87.
- Banham, A.H. et al. (2001) Cancer Res 61, 8820-9.
- Wlodarska, I. et al. (2005) Leukemia 19, 1299-305.
- Goatly, A. et al. (2008) Mod Pathol 21, 902-11.
Limited Uses
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