FoxP3 (D2W8E) Rabbit mAb #98377
- IHC
Supporting Data
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 45 |
| Source/Isotype | Rabbit IgG |
Application Key:
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| IHC Leica Bond | 1:50 |
| Immunohistochemistry (Paraffin) | 1:50 - 1:200 |
Storage
For a carrier free (BSA and azide free) version of this product see product #74816.
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
FoxP3 is crucial for the development of T cells with regulatory properties (Treg) (6). Mutations in FoxP3 are associated with immune dysregulation, polyendocrinopathy, enteropathy, and X-linked syndrome (IPEX) (7), while overexpression in mice causes severe immunodeficiency (8). Research studies have shown that FoxP3 functions as a tumor suppressor in several types of cancer (9-11).
- Myatt, S.S. and Lam, E.W. (2007) Nat Rev Cancer 7, 847-59.
- Shu, W. et al. (2001) J Biol Chem 276, 27488-97.
- Lu, M.M. et al. (2002) Gene Expr Patterns 2, 223-8.
- Koon, H.B. et al. (2007) Expert Opin Ther Targets 11, 955-65.
- Li, S. et al. (2004) Mol Cell Biol 24, 809-22.
- Ochs, H.D. et al. (2007) Immunol Res 38, 112-21.
- Bennett, C.L. et al. (2001) Nat Genet 27, 20-1.
- Kasprowicz, D.J. et al. (2003) J Immunol 171, 1216-23.
- Zuo, T. et al. (2007) Cell 129, 1275-86.
- Zuo, T. et al. (2007) J Clin Invest 117, 3765-73.
- Wang, L. et al. (2009) Cancer Cell 16, 336-46.
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