Galectin-8/LGALS8 (F9O3T) Rabbit mAb #45586
- WB
- IP
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 32, 42 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
| Immunohistochemistry (Paraffin) | 1:50 - 1:200 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Galectin-8 (Gal-8; gene name LGALS8), which belongs to the group of tandem-repeat galectins, is important in adaptive and innate immunity with significant roles in host defense as well as tumor progression (reviewed in 2,3). Extracellular galectin-8 promotes cell adhesion through interaction with several cell surface proteins, including integrins (4,5), CD44 (6), CD45 (7), and CD166 (8). Intracellular galectin-8 binds to farnesylated K-Ras4B, regulating MAPK signaling (9). It also exerts a role in xenophagy by binding to glycans exposed on bacterial pathogens and recruiting NDP52 for destruction by autophagy, thereby restricting bacterial proliferation (10,11). Abundant expression of galectin-8 has been observed in various cancer types and, in some cases, associated with poor prognosis (12-14).
- Johannes, L. et al. (2018) J Cell Sci 131, jcs208884. doi: 10.1242/jcs.208884.
- Purić, E. et al. (2024) Med Res Rev, doi: 10.1002/med.22041.
- Zick, Y. (2022) Biochem Soc Trans 50, 135-149.
- Cárcamo, C. et al. (2006) Exp Cell Res 312, 374-86.
- Hadari, Y.R. et al. (2000) J Cell Sci 113 ( Pt 13), 2385-97.
- Eshkar Sebban, L. et al. (2007) J Immunol 179, 1225-35.
- Tribulatti, M.V. et al. (2009) J Leukoc Biol 86, 371-80.
- Delgado, V.M. et al. (2011) FASEB J 25, 242-54.
- Meinohl, C. et al. (2019) Cancers (Basel) 12, 30. doi: 10.3390/cancers12010030.
- Thurston, T.L. et al. (2012) Nature 482, 414-8.
- Kim, B.W. et al. (2013) Nat Commun 4, 1613.
- Wang, Y. et al. (2023) Am J Cancer Res 13, 2517-2529.
- Gentilini, L.D. et al. (2017) Oncotarget 8, 44654-44668.
- Elola, M.T. et al. (2014) Histol Histopathol 29, 1093-105.
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