Gasdermin C (F9R3M) Rabbit mAb #61921
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 59 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Overexpression of Gasdermin C (GSDMC) in several types of cancer has been associated with disease progression and prognosis (8-13). Cleavage of GSDMC can be induced by caspase-8, with the N-terminal fragment initiating pyroptosis (14,15).
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- Aglietti, R.A. et al. (2016) Proc Natl Acad Sci USA 113, 7858-63.
- Ding, J. et al. (2016) Nature 535, 111-6.
- Liu, X. et al. (2016) Nature 535, 153-8.
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- Watabe, K. et al. (2001) Jpn J Cancer Res 92, 140-51.
- Miguchi, M. et al. (2016) PLoS One 11, e0166422.
- Wei, J. et al. (2020) Mol Med Rep 21, 360-370.
- Cui, Y.Q. et al. (2021) Biomed Res Int 2021, 5282894.
- Yan, C. et al. (2022) J Transl Med 20, 455.
- Li, M. et al. (2023) Front Biosci (Landmark Ed) 28, 235.
- Hou, J. et al. (2020) Nat Cell Biol 22, 1264-1275.
- Zhang, J.Y. et al. (2021) Cell Res 31, 980-997.
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