Name: GIGYF2 (E7F7I) Rabbit mAb
Price: 327.00 USD
Availability: InStock

Filter:

WB
IP

Supporting Data

REACTIVITY	H M
SENSITIVITY	Endogenous
MW (kDa)	180
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human
M-Mouse

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:100

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

GIGYF2 (E7F7I) Rabbit mAb recognizes endogenous levels of total GIGYF2 protein.

Species Reactivity:

Human, Mouse

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser1091 of human GIGYF2 protein.

Background

Grb10-interacting GYF protein 2 (GIGYF2) is part of a macromolecular protein complex, which also contains 4EHP, that functions to repress the translation of a distinct subset of mRNAs during embryonic development. Indeed, disruption of 4EHP and GIGYF2 complex formation prevents normal embryonic development in mice (1). Research studies have also demonstrated that GIGYF2 is involved in repressing translation of defective mRNAs, which prevents expression of potentially toxic protein products (2). In addition to its role in repression of protein translation, GIGYF2 may cooperate with the Grb10 adapter protein to regulate signaling of receptor tyrosine kinases (3).

Database Links

UniProt ID: Q6Y7W6

Entrez-Gene Id: 26058

Limited Uses

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Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

For Research Use Only. Not For Use In Diagnostic Procedures.

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GIGYF2 (E7F7I) Rabbit mAb #31638