GLI3 (E6E2K) Rabbit mAb #71107
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 200 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Initially characterized as a negative regulator of Sonic hedgehog (Shh) signaling (6), follow-up studies described GLI3 as both a transcriptional activator and repressor, similar to GLI2 (7). GLI3 is upregulated in multiple cancers (8,9) but has also been shown to play an anti-cancerous role in acute myeloid leukemia (AML) and medulloblastoma (10,11).
- Kinzler, K.W. et al. (1987) Science 236, 70-3.
- Ruppert, J.M. et al. (1991) Mol Cell Biol 11, 1724-8.
- Kinzler, K.W. et al. (1988) Nature 332, 371-4.
- Ingham, P.W. and McMahon, A.P. (2001) Genes Dev 15, 3059-87.
- McMahon, A.P. et al. (2003) Curr Top Dev Biol 53, 1-114.
- Marigo, V. et al. (1996) Dev Biol 180, 273-83.
- Sasaki, H. et al. (1999) Development 126, 3915-24.
- Li, J. et al. (2018) Biochem Biophys Res Commun 503, 2101-2107.
- Ma, Y. et al. (2018) J Cell Biochem 119, 5324-5331.
- Miyahara, H. et al. (2014) Neuropathology 34, 1-10.
- Chaudhry, P. et al. (2017) Blood 129, 3465-3475.
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