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Product last modified at: 2025-01-01T09:04:55.769Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

GLUL (D2O3F) Rabbit mAb (IHC Formulated) #27857

Filter:
  • IHC
Immunohistochemistry Image 1: GLUL (D2O3F) Rabbit mAb (IHC Formulated)
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using GLUL (D2O3F) Rabbit mAb (IHC Formulated).

To Purchase # 27857

Cat. # Size Qty. Price Ships
27857T 20 µl
$153 Jan 22
27857S 100 µl
$339 Jan 22

Supporting Data

REACTIVITY H M R
SENSITIVITY Endogenous
MW (kDa)
Source/Isotype Rabbit IgG
Application Key:
  • IHC-Immunohistochemistry 
Species Cross-Reactivity Key:
  • H-Human 
  • M-Mouse 
  • R-Rat 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Immunohistochemistry (Paraffin) 1:200

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

GLUL (D2O3F) Rabbit mAb (IHC Formulated) recognizes endogenous levels of total GLUL protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala297 of human GLUL protein.

Background

Glutamate-ammonia ligase (GLUL), also known as glutamine synthetase (GS), catalyzes the de novo synthesis of glutamine from glutamate and ammonia. GLUL is ubiquitously expressed with particularly high expression in the muscle, liver, and brain (1). GLUL expression is elevated in various cancers. Its expression is upregulated by oncogenic c-Myc (2). High expression of GLUL in breast cancer patients is associated with larger tumor size and high level of HER2 expression. It is a predictor of poor survival in patients with glioma and liver cancers (3-6).
For Research Use Only. Not For Use In Diagnostic Procedures.
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