Render Target: STATIC
Render Timestamp: 2024-12-26T11:23:00.572Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 01:57:04.318
Product last modified at: 2024-12-17T19:04:33.013Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

GPR37L1 (D8F5Q) Rabbit mAb #93782

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 48
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    GPR37L1 (D8F5Q) Rabbit mAb recognizes endogenous levels of total GPR37L1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala53 of human GPR37L1 protein.

    Background

    GPR37-like receptor (GPR37L1), also known as endothelin B receptor-like protein 2 (ETBR-LP-2) and GPCR/CNS2, is an orphan G protein coupled-receptor (1,2,3). GPR37L1 and its closely related receptor, GPR37, are endothelin receptor-like GPCRs that are highly expressed in the central nervous system. GPR37L1 is broadly expressed in the brain and regulates multiple neuronal functions, including cerebellar development (4). Studies also indicate that GPR37L1 and GPR37 may be receptors for prosaposin and prosaptide. Peptide-dependent modulation of GPR37L1 activity may regulate neuronal and glial survival, as prosaposin is known to exert neuroprotective, neurotrophic, and gliotrophic actions. (5,6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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