Granzyme M (E7B4W) Rabbit mAb #37765
- WB
Supporting Data
REACTIVITY | H |
SENSITIVITY | Endogenous |
MW (kDa) | 25-30 |
Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
Application | Dilution |
---|---|
Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Granzyme M prefers to cleave after a Methionine or Leucine residue, and proteolyzes a restricted set of macromolecular substrates (4-7). Granzyme M is highly expressed in NK, NKT, γδ T cells, and in differentiated effector CD8+ T cells, suggesting a role for Granzyme M in both innate and adaptive immunity (4-11). After perforin-mediated entry into a target cell, various reports show Granzyme M can induce apoptosis and tumor cell death, stimulate LPS-mediated inflammation, or inhibit viral replication (4,11-15).
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- de Poot, S.A. and Bovenschen, N. (2014) Cell Death Differ 21, 359-68.
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- Kelly, J.M. et al. (1996) Immunogenetics 44, 340-50.
- Mahrus, S. et al. (2004) J Biol Chem 279, 54275-82.
- Smyth, M.J. et al. (1995) Immunogenetics 42, 101-11.
- de Koning, P.J. et al. (2010) Mol Immunol 47, 903-11.
- Bade, B. et al. (2005) Int Immunol 17, 1419-28.
- van Domselaar, R. et al. (2013) Cell Death Differ 20, 419-29.
- Lu, H. et al. (2006) J Immunol 177, 1171-8.
- de Poot, S.A. et al. (2014) Cell Death Differ 21, 416-26.
- van Domselaar, R. et al. (2010) J Immunol 185, 7605-13.
- Anthony, D.A. et al. (2010) J Immunol 185, 1794-803.
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