HAP40 (F2T4T) Rabbit mAb #53720
- WB
- IP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 40 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Huntingtin-associated protein 40 (HAP40), encoded by the F8A1 gene, is a known binding partner of huntingtin (2). HAP40 acts as a central regulator of huntingtin, necessary for the protein’s stability and normal function and has been shown to modulate huntingtin aggregation and toxicity in mouse and Drosophila models of HD, showing potential for HAP40 as a therapeutic target (3,4).
Limited Uses
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