Render Target: STATIC
Render Timestamp: 2024-11-22T12:09:57.117Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 01:58:39.193
Product last modified at: 2024-11-11T17:00:08.972Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

IFIT3 (E8G5Y) Rabbit mAb #47676

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 60-65
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:10 - 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    IFIT3 (E8G5Y) Rabbit mAb recognizes endogenous levels of total IFIT3 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro353 of human IFIT3 protein.

    Background

    IFIT3 (Interferon-induced protein with tetratricopeptide repeats 3; Retinoic acid-induced gene G protein (RIG-G)) is part of the IFIT family of interferon-stimulating genes known for their antiviral properties (1,2). IFIT3 is widely expressed in T cells, B cells, plasmacytoid and myeloid dendritic cells, neurons, and kidney cells (3,4). In response to RNA viral infection, IFIT3 regulates IRF3 activation through interaction with TBK1 and MAVS on the mitochondrion (5). IFIT3 also interacts with IFIT1, leading to inhibitory activity against viral RNA lacking the 2′-O-methylation in the cap structure (6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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