Render Target: STATIC
Render Timestamp: 2024-11-19T11:56:24.698Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 01:55:58.657
Product last modified at: 2024-10-16T12:00:39.722Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77

IGBP1 (5F6) Mouse mAb #5699

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 42
    Source/Isotype Mouse IgG1
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    IGBP1 (5F6) Mouse mAb recognizes endogenous levels of total IGBP1 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to human IGBP1.

    Background

    Immunoglobulin binding protein 1 (IGBP1) interacts with the regulatory subunit C of serine/threonine phosphatase PP2A, and other protein phosphotases, PP4 and PP6 (1-3). Binding of IGBP1 to PP2A has been shown to regulate PP2A catalytic activity and its substrate specificity (1-4). Recent evidence suggests that IGBP1 may play a role in PP2Ac ubiquitination via its association with E3 ubiquitin ligase MID1 (5,6). IGBP1 negatively regulates apoptosis by targeting PP2A activity to suppress p38 mitogen-activated protein kinase activation by cytokines (7). Upon BCR cross-linking, IGBP1 transiently associates with tyrosine phosphorylated molecules, which in turn induce downstream signal transduction (7). Evidence suggests that IGBP1 association with PP2A may be involved in the rapamycin sensitive mTOR pathway (8,9). Formation of the IGBP1 and Midline ring finger protein (MID) complex has been identified as a prerequisite to pathogenesis of X-linked Optiz GBBB syndrome (10).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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