Ikaros (D6N9Y) Rabbit mAb (BSA and Azide Free) #30979
- WB
- IHC
- IF
- F
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 50-70 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
- IF-Immunofluorescence
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.
Formulation
For standard formulation of this product see product #14859.
Storage
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Ikaros (IKZF1, LYF1) is the prototypical Ikaros family zinc-finger transcription factor and is expressed abundantly in lymphoid cells. Genetic studies in mice demonstrate that Ikaros is a tumor suppressor that is important for the normal development of B, T, natural killer, and dendritic cells (3,4). Additional studies show that imbalanced expression of different Ikaros isoforms, as well as mutations in the corresponding IKAROS gene, can be associated with a number of hematologic malignancies in humans (2,5,6).
- Perdomo, J. et al. (2000) J Biol Chem 275, 38347-54.
- Rebollo, A. and Schmitt, C. (2003) Immunol Cell Biol 81, 171-5.
- Georgopoulos, K. et al. (1997) Annu Rev Immunol 15, 155-76.
- Nichogiannopoulou, A. et al. (1998) Semin Immunol 10, 119-25.
- Tonnelle, C. et al. (2002) Leuk Lymphoma 43, 29-35.
- Martinelli, G. et al. (2009) J Clin Oncol 27, 5202-7.
Limited Uses
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