IL-13RA2/CD213a2 (E7U7B) Rabbit mAb #85677
- WB
- IP
- IHC
- F
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 55, 65 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
- IHC-Immunohistochemistry
- F-Flow Cytometry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
| IHC Leica Bond | 1:50 - 1:200 |
| Immunohistochemistry (Paraffin) | 1:100 - 1:400 |
| Flow Cytometry (Live) | 1:50 |
Storage
For a carrier free (BSA and azide free) version of this product see product #68588.
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
IL-13 receptor alpha-2 (IL-13RA2/CD213a2) is a type-I monomeric transmembrane glycoprotein and component of the IL-4/IL-13 receptor system. Research studies have shown that IL-13RA2 controls IL-13 signaling by serving as a high affinity decoy receptor for IL-13, but not IL-4, in a variety of cellular contexts (4,5). Some studies, however, have suggested that signaling through IL-13RA2 expressed on immunosuppressive myeloid cells facilitates tumor immune evasion through the production of TGF-β (6,7).
IL-13RA2 displays a highly restricted expression pattern in normal human tissues, which positions this receptor as a potentially novel therapeutic target for multiple types of solid tumors (8-10). Indeed, research studies have shown that IL-13RA2 is highly over expressed in glioblastomas (11), which has prompted investigation of different IL-13RA2-directed immunotherapies to treat this cancer (12-14).
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- Fichtner-Feigl, S. et al. (2006) Nat Med 12, 99-106.
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- Taguchi, A. et al. (2014) Cancer Res 74, 4694-705.
- Beard, R.E. et al. (2013) Clin Cancer Res 19, 4941-50.
- Jarboe, J.S. et al. (2007) Cancer Res 67, 7983-6.
- Brown, C.E. et al. (2015) Clin Cancer Res 21, 4062-72.
- Brown, C.E. et al. (2012) Clin Cancer Res 18, 2199-209.
- Mintz, A. et al. (2008) Cancer Biother Radiopharm 23, 581-9.
Limited Uses
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