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XML generation date: 2024-12-18 18:01:10.486
Product last modified at: 2024-10-05T08:00:12.561Z
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PDP - Template Name: Antibody Sampler Kit
PDP - Template ID: *******4a3ef3a
  1. Products /
  2. Primary Antibodies /
  3. Immunosuppressive Tumor Microenvironment IHC Antibody Sampler Kit

Immunosuppressive Tumor Microenvironment IHC Antibody Sampler Kit #67524

    Product Information

    Kit Usage Information

    Protocols

    Product Description

    The Immunosuppressive Tumor Microenvironment IHC Antibody Sampler Kit provides an economical means of detecting CD8+ T cells and various markers of immunosuppressive cell types and mechanisms in formalin-fixed paraffin-embedded human tumor tissue samples.

    Background

    The immune system has the capability to detect and eliminate tumor cells, most notably through cytotoxic CD8+ T cell recognition of tumor antigens presented on the surface of tumor cells by MHC class I molecules. However, anti-tumor immune cells can be subject to various immunosuppressive mechanisms in the tumor microenvironment (TME). One of these mechanisms is the upregulation of PD-L1 by tumor cells and myeloid cells, which suppresses T cell function through interaction with PD-1 (1,2). In addition, the tumor can recruit immunosuppressive cells, such as FoxP3+ regulatory T cells, and can promote polarization of cells to a pro-tumor and immunosuppressive phenotype, such as CD68+CD206+M2-like macrophages (3,4). The infiltration and function of cytotoxic CD8+ T cells can also be suppressed by stromal cells such as LRRC15+ immunosuppressive cancer-associated fibroblasts (CAFs) (5).

    Database Links

    UniProt ID: P22897 , Q9NZQ7 , P01732 , Q9BZS1 , P34810 , Q8TF66


    Entrez-Gene Id: 4360 , 29126 , 925 , 50943 , 968 , 131578


    Limited Uses

    Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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