Integrin α1/CD49a (E9K2J) XP® Rabbit mAb (BSA and Azide Free) #93908
- WB
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 200 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
This product is the carrier-free version of product #15574. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol.
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN, or CUT&Tag assays. If you require a carrier-free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.Formulation
Supplied in 1X PBS (10 mM Na2HPO4, 3 mM KCl, 2 mM KH2PO4, and 140 mM NaCl (pH 7.8)). BSA and Azide Free.
For standard formulation of this product see product #15574.
Storage
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Integrin α1 (CD49a, VLA-1, ITGA1) pairs with integrin β1 to form an α1β1 dimer on the cell surface. This integrin dimer plays important roles in colorectal cancer and pancreatic cancer cell proliferation, migration, and metastasis (4-6). The cytoplasmic tail of integrin α1 activates ERK and FAK/Src signaling to promote these biological processes (7,8). In immune systems, integrin α1 expression defines a tissue-resident cytotoxic T cell population contributing to both cancer immunity and vitiligo, an autoimmune disease (9,10).
- Liu, S. et al. (2000) J Cell Sci 113 (Pt 20), 3563-71.
- Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2, 91-100.
- Hogervorst, F. et al. (1993) J Cell Biol 121, 179-91.
- Gharibi, A. et al. (2017) Sci Rep 7, 10060.
- Boudjadi, S. et al. (2017) Cancers (Basel) 9, pii: E96. doi: 10.3390/cancers9080096.
- Shang, L. et al. (2017) Oncotarget 8, 76816-31.
- Abair, T.D. et al. (2008) Blood 112, 3242-54.
- Van Slambrouck, S. et al. (2007) Int J Oncol 31, 1501-8.
- Cheuk, S. et al. (2017) Immunity 46, 287-300.
- Molodtsov, A. and Turk, M.J. (2018) Front Immunol 9, 2810.
Limited Uses
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