Integrin α2 Antibody #88228
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 170 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Integrin alpha-2, also known as cluster of differentiation 49b, forms a heterodimer with integrin beta-1. This integral membrane receptor complex interacts with extracellular matrix molecules laminin, collagen, collagen C-propeptides, fibronectin, and E-cadherin (3-6). It can also act as a receptor for viral pathogens (7,8). Integrin alpha-2/beta-1 is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, and force generation and organization of newly synthesized extracellular matrix (3).
- Hood, J.D. and Cheresh, D.A. (2002) Nat Rev Cancer 2, 91-100.
- Liu, S. et al. (2000) J Cell Sci 113 ( Pt 20), 3563-71.
- Adorno-Cruz, V. and Liu, H. (2019) Genes Dis 6, 16-24.
- Languino, L.R. et al. (1989) J Cell Biol 109, 2455-62.
- Yuan, Y. et al. (2016) Life Sci 149, 138-45.
- Whittard, J.D. et al. (2002) Matrix Biol 21, 525-32.
- Graham, K.L. et al. (2003) J Virol 77, 9969-78.
- Bergelson, J.M. et al. (1993) J Virol 67, 6847-52.
Limited Uses
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