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Render Timestamp: 2024-11-22T11:18:33.671Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-10-21 20:01:08.596
Product last modified at: 2024-09-03T21:45:07.828Z
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PDP - Template Name: Antibody Sampler Kit
PDP - Template ID: *******4a3ef3a
  1. Products /
  2. Primary Antibodies /
  3. IRF Family Antibody Sampler Kit

IRF Family Antibody Sampler Kit #57103

    Product Information

    Kit Usage Information

    Protocols

    Product Description

    The IRF Family Antibody Sampler Kit contains reagents to examine the total protein levels of various IRF isoforms. The kit contains enough primary and secondary antibodies to perform two western blot experiments with each primary antibody.

    Specificity / Sensitivity

    Each antibody in the IRF Family Antibody Sampler Kit detects endogenous levels of its target protein. IRF-8 (D20D8) Rabbit mAb also detects an unknown background band at 80 kDa in some cell lines. IRF-9 (D2T8M) Rabbit mAb cross-reacts with an unidentified protein at 95 kDa.

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with synthetic peptides corresponding to residues surrounding Pro261 of human IRF-1, Pro115 of human IRF-7, and Gly65 of human IRF-8, or recombinant human IRF-3, mouse IRF-4, and human IRF-9 proteins. Polyclonal antibodies are produced by immunizing animals with synthetic peptides corresponding to residues surrounding Asp327 of human IRF-2, Gly121 of human IRF-6, and near the carboxy terminus of human IRF-5. Antibodies were purified by affinity chromatography.

    Background

    Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, IRF-9/ISGF3γ, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2).

    Database Links

    UniProt ID: Q92985 , Q00978 , Q64287 , Q13568 , Q14653 , P10914 , Q02556 , O14896 , P14316


    Entrez-Gene Id: 3665 , 10379 , 16364 , 3663 , 3661 , 3659 , 3394 , 3664 , 3660


    Limited Uses

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    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
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