KCNK6 Antibody #92295
- WB
- IP
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 35, 70 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
KCNK6, also known as TWIK-2, is expressed in all human tissues examined except the skeletal muscle (5). A recent study identified KCNK6 as the K+ channel mediating K+ efflux across the plasma membrane that is essential for NLRP3 inflammasome activation (6).
- Goldstein, S.A. et al. (2001) Nat Rev Neurosci 2, 175-84.
- Kim, D. and Kang, D. (2015) Pflugers Arch 467, 1001-11.
- Enyedi, P. and Czirják, G. (2010) Physiol Rev 90, 559-605.
- Mathie, A. et al. (2021) Annu Rev Pharmacol Toxicol, 61:401-420.
- Chavez, R.A. et al. (1999) J Biol Chem 274, 7887-92.
- Di, A. et al. (2018) Immunity 49, 56-65.e4.
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